J postgrad med 2005 51 243-4. Tinidazole, despite considerable use worldwide, has not been linked convincingly to instances of clinically apparent liver injury with jaundice. Obstet gynecol 2007 110 (2 pt 1) 302-9.
In instances of allergic reactions or anaphylaxis, rechallenge should be avoided. New york mcgraw hill, 2012, pp. Hypersensitivity reactions to tinidazole (fasigyn).
Escobedo aa, alvarez g,gonzlez me, almirall p,cañete r, cimerman s, ruiz a, et al. Side effects can include metallic or bitter taste, fatigue, dizziness, headache, dyspepsia, nausea, and a disulfiram-like response to alcohol. Clin ther 2005 27 (12) 1859-84.
Livengood ch 3rd, ferris dg, wiesenfeld hc, hillier sl, soper de, nyirjesy p, marrazzo j, et al. Tinidazole is extensively metabolized in the liver largely via cyp 3a4 and can lead to significant drug-drug interactions. Plasma half-life is 12 to 14 hours.
Oral tinidazole is generally well tolerated if being used generally for only 1 to 5 days. The treatment of giardiasis in children single-dose tinidazole compared with 3 days of nitazoxanide. Ast 231 ul, ck 1498 ul, resolving within a few days and liver tests being normal two weeks later).
New rochelle, ny medical letter, inc. Tinidazole is also capable of causing anaphylactic and allergic reactions including urticaria, angioedema and bronchospasm, reactions which can be associated with minor serum enzyme elevations. In, katzung bg, masters sb, trevor aj. Tinidazole is an orally available, broad spectrum antimicrobial agent used in the treatment of bacterial, protozoal and parasitic infections. Not in pubmed (thorough description of drugs for parasitic infections in adults and children as well as a table of their major side effects tinidazole, like metronidazole, is considered a first line agent for treatment of amebiasis, giardiasis and trichomonas infections side effects are listed as occasional metallic taste, gi symptoms, rash and rare weakness).
Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the united states. Clin ther 2005 27 (12) 1859-84. Escobedo aa, alvarez g,gonzlez me, almirall p,cañete r, cimerman s, ruiz a, et al. The treatment of giardiasis in children single-dose tinidazole compared with 3 days of nitazoxanide. The cause of rare instance of serum enzyme elevations with tinidazole therapy is unknown, but is likely to be immunologically mediated.
Efficacy of 5-nitroimidazoles for the treatment of giardiasis a systematic review of randomized controlled trials. Med j aust 1983 may 28 1 (11) 498-9. In ullmanns encyclopedia of industrial chemistry 2002 wiley-vch, edwards, david i. Anaphylaxis and hypersensitivity syndrome reactions in increasing severity following repeated exposure to tinidazole. Obstet gynecol 2007 110 (2 pt 1) 302-9.
J postgrad med 2005 51 243-4. Us between 20, more than 100 agents were implicated and the most commonly implicated class of agents was antibiotics, but no case was attributed to tinidazole or metronidazole). Ann trop med parasitol 2008 102 199-207. Drug-induced acute liver failure results of a u. Tinidazole may also be used to treat a variety of other bacterial infections (e. Med lett drugs ther 2004 46 (1190) 70-2. Ast 231 ul, ck 1498 ul, resolving within a few days and liver tests being normal two weeks later). Mechanism of action journal of antimicrobial chemotherapy 1993, volume 31, pp. Stevens johnson syndrome within a few days of starting tinidazole and norfloxacin, and had recurrence after starting single doses of both and another a third time when he took a half a pill of tinidazole alone, having previously tolerated metronidazole no mention of liver involvement or alt levels). In, brunton ll, chabner ba, knollman bc, eds.Learn about Tindamax (Tinidazole) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.